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| 序号 | 时间 | 期刊名 | 2024 IF | 文章标题 | 方法 | 物种 | 来源 |
| 1 | 2015 | Lancet | 98.4 | HMG-coenzyme A reductase inhibition, type 2 diabetes, and bodyweight: evidence from genetic analysis and randomised trials | 遗传学研究、他汀类药物试验的 Meta 分析、统计分析 | 人 | doi:10.1016/S0140- 6736(14)61183-1 |
| 2 | 2022 | Nature | 50.5 | Rolling back of human pluripotent stem cells to an 8-cell embryo-like stage | RRBS、微量WGBS、 scRNA-seq、scATAC-seq、 SMART-seq2 |
人体胚胎细胞 | https://doi.org/10.1038/s41586- 022-04625-0 |
| 3 | 2023 | Cell | 45.5 | Live birth of chimeric monkey with high contribution from embryonic stem cells | 微量WGBS、SMART-seq2 | 食蟹猴 | DOI:10.1016/j.cell.2023.10.005 |
| 4 | 2009 | Science | 44.7 | Complete resequencing of 40 genomes reveals domestication events and genes in silkworm (Bombyx) | 全基因组重测序 | 家蚕 | doi: 10.1126/science.1176620 |
| 5 | 2017 | Cell Res | 28.1 | De novo DNA methylation during monkey pre-implantation embryogenesis | 微量WGBS | 猕猴，胚胎细胞 | DOI:10.1038/cr.2017.25 |
| 7 | 2014 | BLOOD | 21 | Inherited bone marrow failure associated with germline mutation of ACD, the gene encoding telomere protein TPP1 | WES、孟德尔遗传分析、 qPCR、qRT-PCR、ChIP | 人，外周血 | DOI:10.1182/blood-2014-08- 596445 |
| 20 | 2024 | Nucleic Acids Res | 16.6 | Programmable RNA 5-methylcytosine (m5C) modification of cellular RNAs by dCasRx conjugated methyltransferase and demethylase |
RNA-BS | 细胞 | doi.org/10.1093/nar/gkae110 |
| 21 | 2023 | Nucleic Acids Res | 16.6 | A meet-up of acetyl phosphate and c-di-GMP modulates BldD activity for development and antibiotic production | ChIP-seq | 细菌 | doi:10.1093/nar/gkad494 |
| 22 | 2022 | Nucleic Acids Res | 16.6 | Schlafen 5 suppresses human immunodeficiency virus type 1 transcription by commandeering cellular epigenetic machinery |
ChIP-seq | 小鼠，细胞 | doi:10.1093/nar/gkac489 |
| 8 | 2024 | Nat Commun | 14.7 | Non-invasive modulation of meningeal lymphatics ameliorates ageing and Alzheimer's disease-associated pathology and cognition in mice |
Smart-seq2 | 小鼠脑膜组织 | doi: 10.1038/s41467-024- 45656-7 |
| 9 | 2024 | Nat Commun | 14.7 | Allosteric regulation by c-di-AMP modulates a complete N- acetylglucosamine signaling cascade in Saccharopolyspora erythraea |
EMSA 、ChIP-seq、qRT- PCR | 细菌 | doi: 10.1038/s41467-024- 48063-0 |
| 10 | 2014 | Nat Commun | 14.7 | The locust genome provides insight into swarm formation and long distance flight | RRBS、RNA-seq、基因组 | 蝗虫 | DOI:10.1038/ncomms3957 |
| 11 | 2014 | Nat Commun | 14.7 | Differential methylation of the TRPA1 promoter in pain sensitivity | MeDIP-seq、450K、焦磷酸测序 | 人，全血 | DOI:10.1038/ncomms3978 |
| 12 | 2014 | Nat Commun | 14.7 | An integrated epigenomic analysis for type 2 diabetes susceptibility loci in monozygotic twins | MeDIP-seq、450K、代谢组 | 人，全血 | DOI:10.1038/ncomms6719 |
| 13 | 2018 | Nat Commun | 14.7 | Obligatory and facilitative allelic variation in the DNA methylome within common disease-associated loci. | MeDIP-seq、GWAS分析、 450K芯片 | 人，全血 | DOI:10.1038/s41467-017- 01586-1 |
| 14 | 2020 | Nat Commun | 14.7 | Transcriptomic and open chromatin atlas of high-resolution anatomical regions in the rhesus macaque brain | ATAC-seq、RNA-seq | 猕猴，脑组织 | DOI:10.1038/s41467-020- 14368-z |
| 15 | 2021 | Nat Commun | 14.7 | The genomic loci of specific human tRNA genes exhibit ageing-related DNA hypermethylation | MeDIP-seq、Target-BS、 RRBS、450K | 人 | DOI:10.1038/s41467-021- 22639-6 |
| 16 | 2020 | Nat Commun | 14.7 | ARTICLE JMJD3 acts in tandem with KLF4 to facilitate reprogramming to pluripotency | RNA-seq、ATAC-seq 、 ChIP-seq |
小鼠，大脑 | DOI:10.1038/s41467-020- 18900-z |
| 18 | 2024 | Advanced Science | 14.3 | Metabolic Recoding of NSUN2-Mediated m5C Modification Promotes the Progression of Colorectal Cancer via the NSUN2/YBX1/m5C-ENO1 Positive Feedback Loop |
RNA-BS、RNA-seq |
人胚胎肾HEK 293T细胞 |
doi: 10.1002/advs.202309840 |
| 17 | 2022 | J Clin Invest | 13.3 | Iron-dependent epigenetic modulation promotes pathogenic T cell differentiation in lupus | MeDIP-Seq 、 hMeDIP-Seq | 小鼠 | DOI:10.1172/JCI152345 |
| 19 | 2024 | Chemical Engineering Journal |
13.3 | Novel strategy to understand the aerobic deterioration of corn silage and the influence of Neolamarckia cadamba essential oil by multi-omics analysis |
宏基因组测序、宏转录组 | 肠道内容物 | DOI:10.1016/j.cej.2024.148715 |
| 6 | 2018 | Cell discovery | 13 | DNA methylation reprogramming of functional elements during mammalian embryonic development | MethylC-seq、RNA-seq | 人，胚胎 | DOI:10.1038/s41421-018-0039- 9 |
| 25 | 2023 | J Hazard Mater | 12.2 | Effects of thiacloprid exposure on microbiota-gut-liver axis: Multiomics mechanistic analysis in Japanese quails | 微生物组16S rRNA 测序、 代谢组LC-MS测序、转录组RNA-seq等 |
日本鹌鹑 | DOI：10.1016/j.jhazmat.2022.130082 |
| 24 | 2020 | Sci Adv | 11.7 | β-Catenin safeguards the ground state of mousepluripotency by strengthening the robustness of the transcriptional apparatus | ChIP-qPCR、GRO-seq、 ATAC-seq、RNA-seq | 人胚胎肾细胞、小鼠 | DOI:10.1126/sciadv.aba1593 |
| 39 | 2022 | GENOM PROTEOM BIOINF |
11.5 | Protein Lactylation and Metabolic Regulation of the Zoonotic Parasite Toxoplasma gondii | ChIP-seq | 弓形虫 | doi: 10.1016/j.gpb.2022.09.010 |
| 23 | 2016 | BRAIN | 10.6 | CSF1R mosaicism in a family with hereditary diffuse leukoencephalopathy with spheroids | 外显子测序、Sanger测序 、扩增子测序 |
人 | DOI:10.1093/brain/aww066 |
| 31 | 2017 | Genome Med | 10.4 | DNA methylation changes at infertility genes in newborn twins conceived by in vitro fertilisation | MeDIP-seq | 人双胞 胎，脐带血 |
DOI:10.1186/s13073-017-0413- 5 |
| 32 | 2022 | Environmen t Internation |
10.3 | Genome-wide alternation and effect of DNA methylation in the impairments of steroidogenesis and spermatogenesis after PM2.5 exposure |
WGBS、RNA-seq、 Western Blot | 小鼠，组织 | DOI:10.1016/j.envint.2022.1075 44 |
| 27 | 2012 | GENOME BIOL | 10.1 | Differential DNA methylation in discrete developmental stages of the parasitic nematode Trichinella spiralis | MethylC-seq、 RNA-seq、qPCR | 大鼠，寄 生虫旋毛虫 |
DOI:10.1186/gb-2012-13-10- r100 |
| 28 | 2014 | GENOME BIOL | 10.1 | Integrated analyses of DNA methylation and hydroxymethylation reveal tumor suppressive roles of ECM1, ATF5, and EOMES in human hepatocellular carcinoma |
HSMT-Seq，RNA-seq | 人，HCC组织 | DOI:10.1186/s13059-014-0533- 9 |
| 29 | 2016 | GENOME BIOL | 10.1 | Novel regional age-associated DNA methylation changes within human common disease-associated loci | MeDIP-seq | 人，外周血 | DOI:10.1186/s13059-016-1051- 8 |
| 30 | 2014 | GENOME BIOL | 10.1 | Hypermethylation in the ZBTB20 gene is associated with major depressive disorder | MeDIP-seq、RNA-seq | 双胞胎人，全血 | DOI:10.1186/gb-2014-15-4-r56 |
| 33 | 2019 | Bioresour Technol | 9.7 | Metatranscriptomics reveals microbial adaptation and resistance to extreme environment coupling with bioleaching performance |
宏转录组 | 嗜酸性菌 株，微生物 |
DOI:10.1016/j.biortech.2019.01. 117 |
| 34 | 2023 | Biomarker Research | 9.5 | Integrative multi-Omics analysis depicts the methylome and hydroxymethylome of recurrent bladder cancers and identifies biomarkers for predicting PD-L1 expression |
oxRRBS RRBS RNA-seq | 人，膀胱 癌组织和癌旁组织 |
https://doi.org/10.21203/rs.3.rs- 2456805/v1 |
| 40 | 2018 | J Neuroinfla mm |
9.3 | Necrotizing enterocolitis is associated with acute brain responses in preterm pigs. | RNA-seq、qPCR | 早产猪 | DOI:10.1186/s12974-018-1201- x |
| 37 | 2012 | Am J Hum Genet | 8.1 | Large-scale gene-centric meta-analysis across 32 studies identifies multiple lipid loci | 基因组、GWAS荟萃分析 、IBC |
人，全血 | DOI:10.1016/j.ajhg.2012.08.032 |
| 38 | 2011 | Am J Hum Genet | 8.1 | Meta-analysis of Dense Genecentric Association Studies Reveals Common and Uncommon Variants Associated with Height |
基因组、IBC | 人 | DOI:10.1016/j.ajhg.2010.11.007 |
| 42 | 2022 | CHEMOSPH ERE | 8.1 | Longitudinal physiological and transcriptomic analyses reveal the short term and long term response of Synechocystis sp. PCC6803 to cadmium stress | 原核转录组 | 聚囊藻 PCC6803 |
DOI:10.1016/j.chemosphere.2022. 134727 |
| 43 | 2023 | CHEMOSPH ERE | 8.1 | Effects of single and combined contamination of total petroleum hydrocarbons and heavy metals on soil microecosystems: Insights into bacterial diversity, assembly, and ecological function |
16sRNA | 土壤 | doi: 10.1016/j.chemosphere.2023.1402 88 |
| 26 | 2014 | J Autoimmun |
7.9 | DNA methylation and mRNA and microRNA expression of SLE CD4þ T cells correlate with disease phenotype | DNA甲基化、mRNA-seq、 microRNA-seq | 人，细胞 | DOI:10.1016/j.jaut.2014.07.002 |
| 35 | 2021 | Clin Transl Med | 7.9 | An epigenomic landscape of cervical intraepithelial neoplasia and cervical cancer using single-base resolution methylome and hydroxymethylome |
WGBS-seq、oxWGBS-seq 、RNA-seq |
人，宫颈组织 | DOI:10.1002/ctm2.498 |
| 36 | 2014 | Neurology | 7.7 | TUBB4A de novo mutations cause isolated hypomyelination | 全外显子组测序 | 人，血液 | DOI:10.1212/WNL.0000000000 000754 |
| 41 | 2023 | Cell Reports | 7.5 | A bacteriocyte symbiont determines whitefly sex ratio by regulating mitochondrial function | ChIP-seq | 烟粉虱 | doi:10.1016/j.celrep.2023.1121 02. |
| 62 | 2020 | Journal of Genetics and |
6.6 | Longitudinal epitranscriptome profiling reveals the crucial role of N6-methyladenosine methylation in porcine prenatal skeletal muscle development |
m6A-seq（MeRIP-seq）、 RNA-seq、IGF2BP1 RIP-seq | 猪，组织 | https://doi.org/10.1016/j.jgg.2020. 07.003 |
| 44 | 2023 | MOL THER- NUCL ACIDS | 6.5 | Epigenetic Inactivation of SOX30 Is Associated with Male Infertility and Offers a Therapy Target for Non-obstructive Azoospermia |
WGBS | 睾丸活检标本 | doi: 10.1016/j.omtn.2019.10.038 |
| 49 | 2023 | Plant Physiol | 6.5 | RNA m6A modification facilitates DNA methylation during maize kernel development | BS-seq、MeRIP-seq | 玉米 | DOI:10.1093/plphys/kiad625 |
| 53 | 2024 | J Anim Sci Biotechnol | 6.3 | Effects of maternal methyl donor intake during pregnancy on ileum methylation and function in an intrauterine growth restriction pig model |
RRBS | 仔猪 | DOI:10.1186/s40104-023- 00970-w |
| 54 | 2023 | J Anim Sci Biotechnol | 6.3 | Whole-genome transcriptome and DNA methylation dynamics of pre-implantation embryos reveal progression of embryonic genome activation in buffaloes |
scWGBS+scRNA-seq | 水牛 | DOI:10.1186/s40104-023- 00894-5 |
| 55 | 2022 | J Anim Sci Biotechnol | 6.3 | Coordinated transcriptional and post-transcriptional epigenetic regulation during skeletal muscle development and growth in pigs |
WGBS、MeRIP-seq | 仔猪 | DOI:10.1186/s40104-022- 00791-3 |
| 45 | 2023 | Cell Mol Life Sci | 6.2 | Single-cell multi-omics profiling reveals key regulatory mechanisms that poise germinal vesicle oocytes for maturation in pigs. |
scWGBS+Smart-seq2 | 母猪卵母细胞 | DOI:10.1007/s00018-023-04873-x |
| 46 | 2024 | Cell Mol Life Sci | 6.2 | CRL4DCAF13 E3 ubiquitin ligase targets MeCP2 for degradation to prevent DNA hypermethylation and ensure normal transcription in growing oocytes |
微量WGBS、RNA-seq | 小鼠胚胎 | doi: 10.1007/s00018-024-05185-4 |
| 56 | 2020 | ECOTOX ENVIRON SAFE | 6.2 | Effects of co-contamination of heavy metals and total petroleum hydrocarbons on soil bacterial community and function network reconstitution | 16S rRNA、ICP | 土壤 | DOI:10.1016/j.ecoenv.2020.111 083 |
| 48 | 2017 | Pain | 5.9 | Genome-wide methylation analysis of a large population sample shows neurological pathways involvement in chronic widespread musculoskeletal pain | MeDIP-seq | 人，全血 | DOI:10.1097/j.pain.0000000000 000880 |
| 50 | 2020 | Front Immunol | 5.7 | Effects of Low-Dose Antibiotics on Gut Immunity and Antibiotic Resistomes in Weaned Piglets | RNA-seq、宏基因组、 ELISA | 仔猪 | DOI:10.3389/fimmu.2020.00903 |
| 51 | 2020 | Front Immunol | 5.7 | Rapid Gut Adaptation to Preterm Birth Involves Feeding- Related DNA Methylation Reprogramming of Intestinal Genes in Pigs |
RRBS、RNA-seq、扩增子测序（16S rRNA） | 仔猪，肠组织 | DOI:10.3389/fimmu.2020.00565 |
| 52 | 2020 | Front Immunol | 5.7 | Postnatal Gut Immunity and Microbiota Development Is Minimally Affected by Prenatal Inflammation in Preterm Pigs | 转录组、宏基因组 | 仔猪 | DOI:10.3389/fimmu.2020.00420 |
| 58 | 2012 | J Invest Dermatol | 5.7 | Array Comparative Genomic Hybridization of Keratoacanthomas and Squamous Cell Carcinomas: Different Patterns of Genetic Aberrations Suggest Two Distinct Entities | 基因组CGH 分析 | 人，SCC病变组织 | DOI:10.1038/jid.2012.104 |
| 47 | 2020 | Mol Ecol Resour | 5.5 | Giant African snail genomes provide insights into molluscan whole-genome duplication and aquatic–terrestrial transition |
基因组 | 非洲大非洲蜗牛 | DOI:10.1111/1755-0998.13261 |
| 59 | 2021 | Cell Biol Toxicol | 5.3 | Sevoflurane impairs m6A-mediated mRNA translation and leads to fine motor and cognitive deficits | MeRIP-seq、RIP | 小鼠 | DOI:10.1007/s10565-021- 09601-4 |
| 61 | 2021 | communica tions biology |
5.2 | Comparative multi-omics analyses reveal differential expression of key genes relevant for parasitism between non- encapsulated and encapsulated Trichinella |
基因组测序、WGBS、 RNA-seq |
大鼠，旋毛虫 | DOI:10.1038/s42003-021- 01650-z |
| 57 | 2019 | Mol Oncol | 5 | A 17 gene panel for non-small-cell lung cancer prognosis identified through integrative epigenomic-transcriptomic analyses of hypoxia-induced epithelial-mesenchymal transition |
MeDIP-seq、hMeDIP-seq 、ChIP-seq、RNA-seq |
人，细胞 | DOI:10.1002/1878-0261.12491 |
| 63 | 2016 | J CLIN ENDOCR METAB | 5 | Contribution of Heritability and Epigenetic Factors to Skeletal Muscle Mass Variation in United Kingdom Twins | MeDIP-seq | 人，全血 | DOI:10.1210/jc.2016-1219 |
| 60 | 2019 | Biol Conserv | 4.9 | Epigenetic and transcriptional signatures of ex situ conserved golden snub-nosed monkeys (Rhinopithecus roxellana) | RRBS、RNA-seq | 金丝猴，粪便 | https://doi.org/10.1016/j.biocon.2 019.06.021 |
| 64 | 2015 | Clin Epigenetics | 4.8 | Global analysis of DNA methylation in hepatocellular carcinoma by a liquid hybridization capture-based bisulfite sequencing approach | 靶向LHC-BS、RNA-seq | 人，组织 | DOI:10.1186/s13148-015-0121- 1 |
| 65 | 2018 | Clin Epigenetics | 4.8 | Integrated analyses of multi-omics reveal global patterns of methylation and hydroxymethylation and screen the tumor suppressive roles of HADHB in colorectal cancer | MeDIP-seq、hMeDIP-seq 、RNA-seq |
人，组织 | DOI:10.1186/s13148-018-0458- 3 |
| 68 | 2019 | J Nutr Biochem | 4.8 | Inter-correlated gut microbiota and SCFAs changes upon antibiotics exposure links with rapid body-mass gain in weaned piglet model |
16S rRNA扩增子测序、 RNA-seq、靶向代谢组 | 仔猪，粪便 | DOI:10.1016/j.jnutbio.2019.108 246 |
| 69 | 2021 | Front Cell Dev Biol | 4.6 | Comparative Epigenomics Reveals Host Diversity of the Trichinella Epigenomes and Their Effects on Differential Parasitism |
全基因组测序、WGBS、 RNA-seq |
大鼠，旋毛虫 | DOI:10.3389/fcell.2021.681839 |
| 72 | 2020 | FASEB J | 4.4 | Prenatal inflammation suppresses blood Th1 polarization and gene clusters related to cellular energy metabolism in preterm newborns | 代谢组、全转录组、qPCR 、ELISA |
猪模型，血液 | DOI:10.1096/fj.201902629R |
| 66 | 2021 | Front Plant Sci | 4.1 | Root Endophytes and Ginkgo biloba Are Likely to Share and Compensate Secondary Metabolic Processes, and Potentially Exchange Genetic Information by LTR-RTs | 代谢组 | 银杏叶 | DOI:10.3389/fpls.2021.704985 |
| 67 | 2019 | Front Plant Sci | 4.1 | Flavonoid Biosynthesis Is Likely More Susceptible to Elevation and Tree Age Than Other Branch Pathways Involved in Phenylpropanoid Biosynthesis in Ginkgo Leaves | 转录组 | 银杏叶 | DOI:10.3389/fpls.2019.00983 |
| 95 | 2012 | J Biotechnol | 4.1 | Systematic assessment of reduced representation bisulfite sequencing to human blood samples: A promising method for large-sample-scale epigenomic studies | RRBS | 人，血液 | DOI:10.1016/j.jbiotec.2011.06.0 34 |
| 70 | 2023 | Front Microbiol | 4 | Dynamic changes of the gut microbial colonization in preterm infants with different time points after birth | 16S rRNA | 人（早产儿），粪便 | DOI:10.3389/fmicb.2023.10784 26 |
| 80 | 2011 | PLoS Genet | 4 | Genome-wide association of bipolar disorder suggests an enrichment of replicable associations in regions near genes | 全基因组 SNP 基因分型、 GWAS |
人 | DOI:10.1371/journal.pgen.1002 134 |
| 81 | 2023 | Plants-Basel | 4 | The Sink-Source Relationship in Cucumber (Cucumis sativus L.) Is Modulated by DNA Methylation | WGBS、RNA-seq | 黄瓜 | DOI:10.3390/plants13010103 |
| 73 | 2024 | Biomedicin es | 3.9 | Transcriptome-Wide N6-Methyladenosine Alternations in Pulmonary Arteries of Monocrotaline-Induced Pulmonary Arterial Hypertension in Rats and Novel Therapeutic Targets | MeRIP-seq、RNA-seq | 大鼠肺动脉组织 | DOI:10.3390/biomedicines1202 0364 |
| 82 | 2021 | AM J PHYSIOL- GASTR L |
3.9 | Subclinical necrotizing enterocolitis-induced systemic immune suppression in neonatal preterm pigs | 转录组 | 新生早产猪模型 | DOI:10.1152/ajpgi.00408.2020 |
| 83 | 2024 | APPL ENVIRON MICROB | 3.9 | Effects of Neolamarckia cadamba leaves extract on microbial community and antibiotic resistance genes in cecal contents and feces of broilers challenged with lipopolysaccharides | 宏基因组 | 肠道内容物 | DOI:10.1128/aem.01107-23 |
| 94 | 2018 | DNA Res | 3.9 | Early microbial colonization affects DNA methylation of genes related to intestinal immunity and metabolism in preterm pigs | RRBS、16S rRNA测序 | 仔猪，粪便 | DOI:10.1093/dnares/dsy001 |
| 74 | 2016 | Scientific Reports | 3.8 | The promoter methylomes of monochorionic twin placentas reveal intrauterine growth restriction-specific variations in the methylation patterns |
LHC-BS、RT-PCR | 人，胎盘组织 | DOI:10.1038/srep20181 |
| 75 | 2016 | Scientific Reports | 3.8 | Filtrating colorectal cancer associated genes by integrated analyses of global DNA methylation and hydroxymethylation in cancer and normal tissue | HMST-seq | 人，CRC样本 | DOI:10.1038/srep31826 |
| 76 | 2016 | Scientific Reports | 3.8 | Stochastic anomaly of methylome but persistent SRY hypermethylation in disorder of sex development in canine somatic cell nuclear transfer | WGBS、全基因组测序 （WGS）、MiSeq 扩增子测序、BSP、qPCR |
母狗，卵母细胞 | DOI:10.1038/srep31088 |
| 77 | 2016 | Scientific Reports | 3.8 | Genome-wide profiles of methylation, microRNAs, and gene expression in chemoresistant breast cancer | RRBS、mRNA-seq+sRNA- seq | 人，乳腺癌细胞 | DOI:10.1038/srep24706 |
| 78 | 2016 | Scientific Reports | 3.8 | Genome-wide landscape of DNA methylomes and their relationship with mRNA and miRNA transcriptomes in oxidative and glycolytic skeletal muscles | MeDIP-seq、RNA-seq | 猪，组织 | DOI:10.1038/srep32186 |
| 79 | 2016 | Scientific Reports | 3.8 | DNA methylation landscape of fat deposits and fatty acid composition in obese and lean pigs | MeDIP-seq、Q-PCR | 猪，组织 | DOI:10.1038/srep35063 |
| 91 | 2017 | Stem Cells Int | 3.8 | Vitrification of Rhesus Macaque Mesenchymal Stem Cells and the Effects on Global Gene Expression. | RNA-seq、qRT-PCR | 猕猴、骨髓细胞 | DOI:10.1155/2017/3893691 |
| 71 | 2016 | Eur J Hum Genet | 3.7 | Lipids, obesity and gallbladder disease in women: insights from genetic studies using the cardiovascular gene-centric 50K SNP array | 基因组 | 人 | DOI:10.1038/ejhg.2015.63 |
| 90 | 2022 | Vet Res | 3.7 | The expression level of chicken telomerase reverse transcriptase in tumors induced by ALV-J is positively correlated with methylation and mutation of its promoter |
靶基因重亚硫酸盐测序 （Target-BS） |
鸡 | DOI:10.1186/s13567-022- 01069-2 |
| 84 | 2011 | BMC Genomics |
3.5 | High resolution profiling of human exon methylation by liquid hybridization capture-based bisulfite sequencing | LHC-BS | 人，外周血 | DOI:10.1186/1471-2164-12-597 |
| 85 | 2013 | BMC Genomics |
3.5 | Double restriction-enzyme digestion improves the coverage and accuracy of genome-wide CpG methylation profiling by reduced representation bisulfite sequencing | RRBS、dRRBS | 细胞 | DOI:10.1186/1471-2164-14-11 |
| 86 | 2014 | BMC Genomics |
3.5 | Marked methylation changes in intestinal genes during the perinatal period of preterm neonates | RRBS | 猪，肠组织 | DOI:10.1186/1471-2164-15-716 |
| 87 | 2009 | BMC Genomics |
3.5 | An Improved Method for Genome Wide DNA Methylation Profiling Correlated to Transcription and Genomic Instability in Two Breast Cancer Cell Lines |
MMSDK甲基化测序 | 人，细胞 | DOI:10.1186/1471-2164-10-223 |
| 88 | 2023 | BMC Genomics |
3.5 | Identification and validation of a DNA methylation-driven gene-based prognostic model for clear cell renal cell carcinoma | RRBS | 肾透明细胞癌组织 DNA提取物 | doi：10.1186/s12864-023- 09416-z |
| 92 | 2011 | Mol Cell Biochem | 3.5 | Regulation of cytokine expression in murine macrophages stimulated by excretory/secretory products from Trichinella spiralis in vitro |
宏基因组 | 螺旋锥 虫，排泄物 |
DOI:10.1007/s11010-011-1046- 4 |
| 89 | 2014 | Genomics | 3.4 | Direct ChIP-bisulfite sequencing reveals a role of H3K27me3 mediating aberrant hypermethylation of promoter CpG islands in cancer cells | ChIP-BS-seq、ChIP-seq、 RNA-seq | 人，细胞 | DOI:10.1016/j.ygeno.2013.12.00 6 |
| 115 | 2021 | Mol Med Rep | 3.4 | De novo assembly and transcriptome characterization: Novel insights into the mechanisms of primary ovarian cancer in Microtus fortis |
RNA-seq | 东方田鼠 | DOI:10.3892/mmr.2021.12580 |
| 105 | 2022 | Pathogens | 3.3 | Intestinal and Mucosal Microbiome Response to Oral Challenge of Enterotoxigenic Escherichia coli in Weaned Pigs | 非靶蛋白质组学和16S扩增子测序 | 断奶猪 | DOI:10.3390/pathogens110201 60 |
| 96 | 2018 | Frontiers in physiology | 3.2 | The Use of Targeted Next Generation Sequencing to Explore Candidate Regulators of TGF-β1's Impact on Kidney Cells |
MeDIP-seq、miRNA-seq、 RNA-seq、ChIP-Seq | 小鼠，细胞 | DOI:10.3389/fphys.2018.01755 |
| 97 | 2014 | Frontiers in physiology | 3.2 | Trichinella spiralis, potential model nematode for epigenetics and its implication in metazoan parasitism | DNA甲基化 | 小鼠，螺旋旋毛虫 | DOI:10.3389/fphys.2013.00410 |
| 110 | 2021 | Pediatr Res | 3.1 | Blood transcriptomic markers of necrotizing enterocolitis in preterm pigs. | 转录组 | 早产仔猪 模型，全血 |
DOI:10.1038/s41390-021- 01605-4 |
| 111 | 2015 | Hum Mol Genet | 3.1 | Mutation in mitochondrial ribosomal protein S7 (MRPS7) causes congenital sensorineural deafness, progressive hepatic and renal failure and lactic acidemia |
WES、线粒体12S rRNA、 16S rRNA | 人 | DOI:10.1093/hmg/ddu747 |
| 114 | 2015 | J PHARMACE UT BIOMED |
3.1 | A transcription/translation-based gene signature predicts resistance to chemotherapy in breast cancer | 细胞 | doi:10.1016/j.jpba.2014.10.018 | |
| 98 | 2013 | Epigenomic s | 3 | Hydroxymethylation- and methylation-sensitive tag sequencing: how will this technology change clinical applications of DNA methylation profiling? |
HMST-seq | 人 | DOI:10.2217/epi.13.33 |
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| 130 | 2015 | BMC Medical Genomics |
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